颈动脉斑块内出血可预测重度颈动脉狭窄患者的复发症状。
Carotid intraplaque hemorrhage predicts recurrent symptoms in patients with high-grade carotid stenosis.
作者信息
Altaf Nishath, MacSweeney Shane T, Gladman John, Auer Dorothee P
机构信息
Department of Academic Radiology, University of Nottingham, Queen's Medical Centre, Nottingham, UK.
出版信息
Stroke. 2007 May;38(5):1633-5. doi: 10.1161/STROKEAHA.106.473066. Epub 2007 Mar 22.
BACKGROUND AND PURPOSE
Carotid intraplaque hemorrhage (IPH), known to be associated with plaque instability, may convey a higher stroke risk. The aim of this study was to assess whether the identification of IPH by MRI predicts recurrent clinical cerebrovascular events.
METHODS
Sixty-six patients with high-grade symptomatic carotid stenosis underwent MRI of the carotid arteries and were followed until carotid endarterectomy or 30 days.
RESULTS
Of the 66 patients with a median follow up of 33.5 days, 44 (66.7%) were found on MRI to have ipsilateral carotid IPH. Fifteen recurrent events were associated with ipsilateral carotid IPH. Only 2 recurrent events occurred in the absence of IPH. IPH increased the risk of recurrent ischemia (hazard ratio=4.8; 95% CI=1.1 to 20.9, P<0.05).
CONCLUSIONS
IPH as detected by MRI predicts recurrent cerebrovascular events in patients with symptomatic high-grade carotid stenosis.
背景与目的
已知颈动脉斑块内出血（IPH）与斑块不稳定相关，可能预示着更高的中风风险。本研究的目的是评估通过MRI识别IPH是否能预测复发性临床脑血管事件。
方法
66例有症状的重度颈动脉狭窄患者接受了颈动脉MRI检查，并随访至颈动脉内膜切除术或30天。
结果
在66例患者中，中位随访时间为33.5天，MRI发现44例（66.7%）有同侧颈动脉IPH。15例复发性事件与同侧颈动脉IPH相关。仅2例复发性事件发生在无IPH的情况下。IPH增加了复发性缺血的风险（风险比=4.8；95%CI=1.1至20.9，P<0.05）。
结论
MRI检测到的IPH可预测有症状的重度颈动脉狭窄患者的复发性脑血管事件。
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