基质金属蛋白酶和金属蛋白酶组织抑制因子在肝纤维化中的表达——一项特别关注抗纤维化策略的系统评价
Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies.
作者信息
Hemmann Stefanie, Graf Jürgen, Roderfeld Martin, Roeb Elke
机构信息
Department of Medicine II, Gastroenterology, University Hospital Giessen and Marburg GmbH, Paul-Meimberg-Str. 5, 35392 Giessen, Germany.
出版信息
J Hepatol. 2007 May;46(5):955-75. doi: 10.1016/j.jhep.2007.02.003. Epub 2007 Mar 5.
In liver tissue matrix metalloproteinases (MMPs) and their specific inhibitors (tissue inhibitors of metalloproteinases, TIMPs) play a pivotal role in both, fibrogenesis and fibrolysis. The current knowledge of the pathophysiology of liver fibrogenesis with special emphasis on MMPs and TIMPs is presented. A systematic literature search was conducted. All experimental models of liver fibrosis that evaluated a defined anti-fibrotic intervention in vivo or in vitro considering MMPs and TIMPs were selected. The methodological quality of all these publications has been critically appraised using an objective scoring system and the content has been summarized in a table.
在肝组织中，基质金属蛋白酶（MMPs）及其特异性抑制剂（金属蛋白酶组织抑制剂，TIMPs）在肝纤维化形成和纤溶过程中均发挥着关键作用。本文介绍了当前关于肝纤维化病理生理学的知识，特别强调了MMPs和TIMPs。进行了系统的文献检索。选择了所有在体内或体外评估针对MMPs和TIMPs进行明确抗纤维化干预的肝纤维化实验模型。使用客观评分系统对所有这些出版物的方法学质量进行了严格评估，并将内容汇总在一个表格中。
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