绿胶霉素G，一种来自浅黄嗜几丁质菌属生物栖居菌的新型抗菌化合物。

Verticillin G, a new antibacterial compound from Bionectra byssicola.

作者信息

Zheng Chang-ji, Park Soo-hee, Koshino Hiroyuki, Kim Young-ho, Kim Won-gon

机构信息

Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Daejeon 305-600, Republic of Korea.

出版信息

J Antibiot (Tokyo). 2007 Jan;60(1):61-4. doi: 10.1038/ja.2007.8.

DOI:10.1038/ja.2007.8

PMID:17390590

Abstract

A new epidithiodioxopiperazine compound named verticillin G along with the known compound verticillin D has been isolated from the mycelium of liquid fermentation cultures of a fungal strain Bionectra byssicola F 120. The structure of verticillin G was determined on the basis of MS and NMR data. Verticillin G inhibited the growth of Staphylococcus aureus including methicillin-resistant and quinolone-resistant S. aureus with MIC (microg/ml) of 3-10.

摘要

从真菌菌株Bionectra byssicola F 120的液体发酵培养菌丝体中分离出一种名为verticillin G的新型环(硫代二氧代哌嗪)化合物以及已知化合物verticillin D。基于质谱和核磁共振数据确定了verticillin G的结构。Verticillin G抑制金黄色葡萄球菌的生长，包括耐甲氧西林和耐喹诺酮的金黄色葡萄球菌，其最低抑菌浓度（微克/毫升）为3至10。