孕妇急性戊型肝炎所致急性肝衰竭的结局

Outcome of acute liver failure due to acute hepatitis E in pregnant women.

作者信息

Banait Vaibhav S, Sandur Virendra, Parikh Falguni, Murugesh M, Ranka Purnima, Ramesh V S, Sasidharan Madhu, Sattar Abid, Kamat Sandhya, Dalal Asha, Bhatia Shobna J

机构信息

Department of Gastroenterology, T N Medical College and BYL Nair Ch. Hospital, Mumbai 400 008, India.

出版信息

Indian J Gastroenterol. 2007 Jan-Feb;26(1):6-10.

PMID:17401226

Abstract

INTRODUCTION

Acute liver failure due to acute hepatitis E carries a high mortality.

METHODS

Clinical and laboratory parameters of 42 pregnant women (median age 25.5 years) with acute liver failure due to acute hepatitis E were retrospectively analyzed.

RESULTS

22 women delivered, whereas pregnancy continued in 20 women. The maternal mortality in these two groups was similar (9/22 [41%] versus 14/20 [70%], p=0.056). However, in patients with grade I, II or III hepatic encephalopathy, delivery of fetus was associated with reduced mortality in those who delivered as against those who continued pregnancy (5/16 (31%) vs. 13/20 (65%), p=0.046). On multivariate analysis, higher grade of encephalopathy at admission was associated with risk of death (p=0.005).

CONCLUSION

Mortality in pregnant women with acute liver failure with acute hepatitis E is high, especially in patients who present with higher grades of encephalopathy.

摘要

引言

急性戊型肝炎所致急性肝衰竭死亡率很高。

方法

对42例因急性戊型肝炎导致急性肝衰竭的孕妇（中位年龄25.5岁）的临床和实验室参数进行回顾性分析。

结果

22例孕妇分娩，20例继续妊娠。两组的孕产妇死亡率相似（22例中有9例[41%]，20例中有14例[70%]，p = 0.056）。然而，在患有I级、II级或III级肝性脑病的患者中，与继续妊娠的患者相比，分娩的患者死亡率降低（16例中有5例[31%] vs. 20例中有13例[65%]，p = 0.046）。多因素分析显示，入院时肝性脑病分级较高与死亡风险相关（p = 0.005）。