来自白合欢树皮的含N-乙酰糖的三萜皂苷。

Triterpenoid saponins with N-acetyl sugar from the bark of Albizia procera.

作者信息

Melek F R, Miyase Toshio, Ghaly N S, Nabil Marian

机构信息

Chemistry of Natural Compounds Department, National Research Center, Dokki 12622, Giza, Egypt.

出版信息

Phytochemistry. 2007 May;68(9):1261-6. doi: 10.1016/j.phytochem.2007.02.023. Epub 2007 Apr 3.

DOI:10.1016/j.phytochem.2007.02.023

PMID:17408707

Abstract

Three (1,2,4) and one known (3) triterpenoid saponins were isolated from the bark of Albizia procera. The saponins were characterized as 3-O-[beta-D-xylopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-(1-->6)-2-acetamido-2-deoxy-beta-D-glucopyranosyl] echinocystic acid (1), 3-O-[alpha-L-arabinopyranosyl-(1-->2)-beta-D-fucopyranosyl-(1-->6)-2-acetamido-2-deoxy-beta-D-glucopyranosyl] echinocystic acid (2) and 3-O-[beta-D-xylopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-(1-->6)-2-acetamido-2-deoxy-beta-D-glucopyranosyl] acacic acid lactone (4). Their structures were elucidated by 1D and 2D NMR experiments, FABMS as well as chemical means. Saponins 1 and 3 exhibited cytotoxicity against HEPG2 cell line with IC50 9.13 microg/ml and 10 microg/ml, respectively.

摘要

从白合欢树皮中分离出了三种（1、2、4）三萜皂苷和一种已知的（3）三萜皂苷。这些皂苷被鉴定为3-O-[β-D-吡喃木糖基-（1→2）-α-L-吡喃阿拉伯糖基-（1→6）-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖基]刺囊酸（1）、3-O-[α-L-吡喃阿拉伯糖基-（1→2）-β-D-吡喃岩藻糖基-（1→6）-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖基]刺囊酸（2）和3-O-[β-D-吡喃木糖基-（1→2）-α-L-吡喃阿拉伯糖基-（1→6）-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖基]阿拉伯酸内酯（4）。通过一维和二维核磁共振实验、快原子轰击质谱以及化学方法对它们的结构进行了阐明。皂苷1和3对人肝癌细胞系HEPG2表现出细胞毒性，IC50分别为9.13微克/毫升和10微克/毫升。