基于干涉仪的结肠癌标本相衬X射线计算机断层扫描：与4.74-T磁共振成像和光学显微镜的对比研究
Interferometer-based phase-contrast X-ray computed tomography of colon cancer specimens: comparative study with 4.74-T magnetic resonance imaging and optical microscopy.
作者信息
Takeda Tohoru, Wu Jin, Lwin Thet Thet, Yoneyama Akio, Hyodo Kazuyuki, Matsuda Yoshimasa, Kose Katsumi
机构信息
Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan.
出版信息
J Comput Assist Tomogr. 2007 Mar-Apr;31(2):214-7. doi: 10.1097/01.rct.0000238004.34505.07.
OBJECTIVE
Phase-contrast X-ray computed tomography (PCCT) with an interferometer can reveal the inner soft tissue structures of biological objects without contrast agent, and the image quality is thought to resemble that of magnetic resonance imaging (MRI). Comparative study among PCCT, MRI, and optical microscopy was undertaken.
METHODS
Three formalin-fixed colon cancer specimens from nude mice were imaged both by PCCT with a reconstructed volumetric resolution of (0.018)3 mm3 and 4.74-T MRI with that of (0.075)3 mm3.
RESULTS
Phase-contrast X-ray computed tomography with an interferometer clearly demonstrated the inner structures of colon cancer masses, such as cancer, necrosis, surrounding tumor vessels, and skin, in a similar way to low-magnified optical microscopic images and had approximately 4.0-fold higher signal-to-noise ratio than MRI.
CONCLUSIONS
With formalin-fixed biological samples, PCCT exhibited higher image quality than MRI and was thought to be suitable for detailed imaging of soft tissue with high volumetric resolution.
目的
带有干涉仪的相衬X射线计算机断层扫描（PCCT）能够在不使用造影剂的情况下揭示生物物体的内部软组织结构，并且其图像质量被认为与磁共振成像（MRI）相似。对PCCT、MRI和光学显微镜进行了对比研究。
方法
对三只来自裸鼠的福尔马林固定结肠癌标本进行成像，分别采用重建体素分辨率为(0.018)³ mm³的PCCT和分辨率为(0.075)³ mm³的4.74-T MRI。
结果
带有干涉仪的相衬X射线计算机断层扫描清晰地展示了结肠癌肿块的内部结构，如癌组织、坏死区域、周围肿瘤血管和皮肤，其成像方式与低倍光学显微镜图像相似，并且信噪比大约比MRI高4.0倍。
结论
对于福尔马林固定的生物样本，PCCT的图像质量高于MRI，被认为适用于具有高体素分辨率的软组织详细成像。
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