[人参皂苷与地塞米松对肝癌患者经动脉化疗栓塞术后肝损伤及肾功能的影响]
[Ginsenosides and dexamethasone in managing the liver injury and renal function after transcatheter arterial chemoembolization for hepatic carcinoma patient].
作者信息
Feng Ying-lu, Ling Chang-quan, Chen Zhe, Li Bai, Gu Wei
机构信息
Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
出版信息
Zhonghua Zhong Liu Za Zhi. 2006 Nov;28(11):844-7.
OBJECTIVE
To observe the protective effect of ginsenosides (GS) or low dose of glucocorticoid dexamethasone (Dex) alone or combined in managing the liver injury and renal function after transcatheter arterial chemoembolization (TACE).
METHODS
120 patients with primary liver carcinoma were randomly divided into four groups (A, B, C, D) with 30 patients in each. Group A was treated with placebo; group B with Dex; group C with GS and group D with Dex plus GS. The changes in liver and renal function after TACE were observe according to the WHO criteria for side effects of anti-cancer drug.
RESULTS
Compared with group A, Dex combined with GS was able to reduce the level of TB, ALT/AST, BUN and Child-grade, which significantly protected the liver and kidney (P < 0. 05). However, Dex or GS alone could also improve some parameters of liver and renal function after TACE (P < 0.05).
CONCLUSION
Dex combined with GS is effective in managing the liver injury and renal function after transcatheter arterial
目的
观察人参皂苷（GS）或低剂量糖皮质激素地塞米松（Dex）单独及联合应用对经动脉化疗栓塞术（TACE）后肝损伤及肾功能的保护作用。
方法
120例原发性肝癌患者随机分为四组（A、B、C、D组），每组30例。A组给予安慰剂；B组给予地塞米松；C组给予人参皂苷；D组给予地塞米松加人参皂苷。根据世界卫生组织抗癌药物副作用标准观察TACE术后肝肾功能变化。
结果
与A组相比，地塞米松联合人参皂苷能降低总胆红素（TB）、谷丙转氨酶/谷草转氨酶（ALT/AST）、血尿素氮（BUN）水平及Child分级，对肝肾功能有显著保护作用（P<0.05）。然而，单独使用地塞米松或人参皂苷也能改善TACE术后肝肾功能的一些参数（P<0.05）。
结论
地塞米松联合人参皂苷对经动脉化疗栓塞术后肝损伤及肾功能有保护作用。
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