酵母GAL基因簇的转录记忆需要SWI/SNF。
SWI/SNF is required for transcriptional memory at the yeast GAL gene cluster.
作者信息
Kundu Sharmistha, Horn Peter J, Peterson Craig L
机构信息
Interdisciplinary Graduate Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
出版信息
Genes Dev. 2007 Apr 15;21(8):997-1004. doi: 10.1101/gad.1506607.
Abstract
Post-translational modification of nucleosomal histones has been suggested to contribute to epigenetic transcriptional memory. We describe a case of transcriptional memory in yeast where the rate of transcriptional induction of GAL1 is regulated by the prior expression state. This epigenetic state is inherited by daughter cells, but does not require the histone acetyltransferase, Gcn5p, the histone ubiquitinylating enzyme, Rad6p, or the histone methylases, Dot1p, Set1p, or Set2p. In contrast, we show that the ATP-dependent chromatin remodeling enzyme, SWI/SNF, is essential for transcriptional memory at GAL1. Genetic studies indicate that SWI/SNF controls transcriptional memory by antagonizing ISWI-like chromatin remodeling enzymes.
摘要
核小体组蛋白的翻译后修饰被认为有助于表观遗传转录记忆。我们描述了酵母中的一个转录记忆案例，其中GAL1的转录诱导速率受先前表达状态的调控。这种表观遗传状态由子细胞继承，但不需要组蛋白乙酰转移酶Gcn5p、组蛋白泛素化酶Rad6p或组蛋白甲基转移酶Dot1p、Set1p或Set2p。相比之下，我们发现ATP依赖的染色质重塑酶SWI/SNF对于GAL1处的转录记忆至关重要。遗传学研究表明，SWI/SNF通过拮抗类ISWI染色质重塑酶来控制转录记忆。
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