Shaywitz Bennett A, Skudlarski Pawel, Holahan John M, Marchione Karen E, Constable R Todd, Fulbright Robert K, Zelterman Daniel, Lacadie Cheryl, Shaywitz Sally E
Department of Pediatrics, Section of Pediatric Neurology, Yale University School of Medicine, New Haven, CT 06510-8064, USA.
Ann Neurol. 2007 Apr;61(4):363-70. doi: 10.1002/ana.21093.
To examine age-related changes in the neural systems for reading in nonimpaired and dyslexic children and adolescents.
Functional magnetic resonance imaging was used to study age-related changes in the neural systems for reading in a cross-sectional sample of 232 right-handed children 7 to 18 years of age (113 dyslexic readers and 119 nonimpaired readers) as they read pseudowords.
In nonimpaired readers, systems in the left anterior lateral occipitotemporal area developed with age, whereas systems in the right superior and middle frontal regions decreased. In contrast, in dyslexic readers, systems in the left posterior medial occipitotemporal regions developed with age. Older nonimpaired readers were left lateralized in the anterior lateral occipitotemporal area; there was no difference in asymmetry between younger and older dyslexic readers.
These findings offer a possible neurobiological explanation for the differences in reading acquisition between dyslexic and nonimpaired readers and provide further evidence of the critical role of the left occipitotemporal region in the development of reading.
研究未患阅读障碍及患阅读障碍的儿童和青少年阅读神经系统中与年龄相关的变化。
采用功能磁共振成像技术，对232名7至18岁的右利手儿童（113名阅读障碍读者和119名未患阅读障碍读者）的阅读神经系统中与年龄相关的变化进行横断面研究，这些儿童在阅读假词时接受检测。
在未患阅读障碍的读者中，左侧前外侧枕颞区的神经系统随年龄发展，而右侧额上回和额中回区域的神经系统则随年龄减退。相比之下，在阅读障碍读者中，左侧后内侧枕颞区的神经系统随年龄发展。年龄较大的未患阅读障碍读者在前外侧枕颞区表现为左侧化；年龄较小和较大的阅读障碍读者在不对称性方面没有差异。
这些发现为阅读障碍读者和未患阅读障碍读者在阅读习得方面的差异提供了一种可能的神经生物学解释，并进一步证明了左侧枕颞区在阅读发展中的关键作用。
