Giacoia G P, Azubuike K
Department of Pediatrics, University of Oklahoma College of Medicine, Tulsa.
Obstet Gynecol Surv. 1991 Nov;46(11):723-32.
A variegated group of autoimmune disorders tend to occur in women during childbearing years. Autoantibodies, often of IgG type, directed against the mother's (self) antigens has been well characterized in a number of these disorders. Transplacental transfer of IgG autoantibodies has been frequently demonstrated without demonstrable ill effects of offspring of affected mothers. However, transient neonatal autoimmune syndromes have been described in a subset of infants born with circulating autoantibodies. The time course of clinical symptomatology often parallels the presumed half life IgG immunoglobulins. This review details the clinical manifestations of different transient neonatal autoimmune syndromes and describes possible pathogenic mechanisms. Autoimmune disorders reviewed include connective tissue disorders, thyroid autoimmune disorders, myasthenia gravis, idiopathic thrombocytopenic purpura, and other uncommon disorders.
一组多样的自身免疫性疾病往往在育龄期女性中出现。在许多这类疾病中，针对母亲（自身）抗原的自身抗体（通常为IgG型）已得到充分表征。IgG自身抗体的胎盘转移经常得到证实，而患病母亲的后代并未出现明显不良影响。然而，在一部分出生时带有循环自身抗体的婴儿中，已描述了短暂性新生儿自身免疫综合征。临床症状的时间进程通常与假定的IgG免疫球蛋白半衰期平行。本综述详细介绍了不同短暂性新生儿自身免疫综合征的临床表现，并描述了可能的致病机制。所综述的自身免疫性疾病包括结缔组织疾病、甲状腺自身免疫性疾病、重症肌无力、特发性血小板减少性紫癜以及其他罕见疾病。
