一种HMGB1细胞因子的直接抑制剂。
A direct inhibitor of HMGB1 cytokine.
作者信息
Girard Jean-Philippe
机构信息
Laboratory of Vascular Biology, Department of Cancer Biology, Institute of Pharmacology and Structural Biology, IPBS-CNRS UMR 5089, 205 route de Narbonne, 31077 Toulouse, France.
出版信息
Chem Biol. 2007 Apr;14(4):345-7. doi: 10.1016/j.chembiol.2007.04.001.
Abstract
HMGB1 and the recently described interleukin-33 (IL-33) are abundant chromatin-associated nuclear factors with potent proinflammatory cytokine activities. In this issue of Chemistry & Biology, Mollica et al. [1] report the identification of the first direct small-molecule inhibitor of HMGB1.
摘要
高迁移率族蛋白B1（HMGB1）以及最近发现的白细胞介素-33（IL-33）是与染色质相关的丰富核因子，具有强大的促炎细胞因子活性。在本期《化学生物学》中，莫利卡等人[1]报告了首个HMGB1直接小分子抑制剂的鉴定结果。
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