意外胆囊癌的临床病理分析：23例报告

A clinicopathological analysis in unsuspected gallbladder carcinoma: a report of 23 cases.

作者信息

Xu Li-Ning, Zou Sheng-Quan

机构信息

Department of Hepatobiliary Surgery of PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.

出版信息

World J Gastroenterol. 2007 Mar 28;13(12):1857-60; discussion 1860-1. doi: 10.3748/wjg.v13.i12.1857.

DOI:10.3748/wjg.v13.i12.1857

PMID:17465481

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4149967/

Abstract

AIM

To study the clinicopathological characteristics of unsuspected gallbladder carcinoma (UGC).

METHODS

We retrospectively studied 23 cases of UGC in Tongji Hospital, and compared their clinicopathological characteristics with 33 cases of preoperatively diagnosed gallbladder carcinoma (PDGC).

RESULTS

The proportion of UGC coexisting with cholecystolithiasis was significantly higher than that of PDGC (chi(2) = 13.53, P < 0.01). The infection rate of hepatitis B virus was 21.74% (5/23) in UGC and 30.30% (10/33) in PDGC. Nine (39.13%) of 23 patients with UGC and 8/33 (24.24) PDGC had contact with schistosome pestilent water. The rate of multiple pregnancies was 56.52% (13/23) in the patients with UGC and 42.42% (14/33) in PDGC. The primary location of the UGC was mostly in the neck and body of the gallbladder, and that of the PDGC was often in the body and bottom. The incidence of Nevin stage I and II UGC was significantly higher than that of PDGC (chi(2) = 4.44, P < 0.05 and chi(2) = 4.96, P < 0.05) while that of Nevin stage V UGC was significantly lower than that of PDGC (chi(2) = 7.59, P < 0.01). According to the grading of carcinoma, the incidence of well-differentiated UGC was significantly higher than that of PDGC (chi(2) = 4.16, P < 0.05), and that of poorly-differentiated UGC was significantly lower than that of PDGC (chi(2) = 4.48, P < 0.05).

CONCLUSION

There are different characteristics between UGC and PDGC, such as in primary location, malignant degree and incidence of coexistence with cholecystolithiasis. Cholecystolithiasis, hepatitis B, schistosome and multiple pregnancies were high risk factors for gallbladder carcinoma.

摘要

目的

研究意外胆囊癌（UGC）的临床病理特征。

方法

我们回顾性研究了同济医院23例UGC病例，并将其临床病理特征与33例术前诊断的胆囊癌（PDGC）病例进行比较。

结果

UGC合并胆囊结石的比例显著高于PDGC（χ² = 13.53，P < 0.01）。UGC中乙肝病毒感染率为21.74%（5/23），PDGC中为30.30%（10/33）。23例UGC患者中有9例（39.13%）、33例PDGC患者中有8例（24.24%）接触过血吸虫疫水。UGC患者的多胎妊娠率为56.52%（13/23），PDGC患者为42.42%（14/33）。UGC的原发部位多在胆囊颈部和体部，而PDGC常位于体部和底部。UGC的Nevin I期和II期发病率显著高于PDGC（χ² = 4.44，P < 0.05和χ² = 4.96，P < 0.05），而UGC的Nevin V期发病率显著低于PDGC（χ² = 7.59，P < 0.01）。根据癌症分级，高分化UGC的发病率显著高于PDGC（χ² = 4.16，P < 0.05），低分化UGC的发病率显著低于PDGC（χ² = 4.48，P < 0.05）。