García-Aparicio Víctor, Malapelle Adeline, Abdallah Zouleika, Doisneau Gilles, Santos José Ignacio, Asensio Juan Luis, Cañada Francisco Javier, Beau Jean Marie, Jiménez-Barbero Jesús
Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
Carbohydr Res. 2007 Sep 3;342(12-13):1974-82. doi: 10.1016/j.carres.2007.03.021. Epub 2007 Mar 28.
The conformational behavior of two C-glycosyl analogues of the sialyl-Tn antigen has been determined by a combination of NMR methods and molecular mechanics calculations. Both compounds show a major solution conformation that is drastically different from the major one of the natural compound.
通过核磁共振方法和分子力学计算相结合，确定了唾液酸化-Tn抗原的两种碳苷类似物的构象行为。两种化合物均显示出一种主要的溶液构象，该构象与天然化合物的主要构象截然不同。
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