Saka Masato, Morioka Jun, Kajiwara Koji, Yoshikawa Koichi, Amano Takayuki, Kubota Hisashi, Nomura Sadahiro, Kato Syoichi, Fujii Masami, Fujisawa Hirosuke, Suzuki Michiyasu
Department of Neurosurgery, Yamaguchi University School of Medicine, Japan.
No Shinkei Geka. 2007 May;35(5):475-9.
A 72-year-old female presented with a lump in the left superior-lateral eyelid. The magnetic resonance imaging showed a well-delineated mass in the left lacrimal gland. The tumor was isointense on both the T1 and T2 weighted images, and it was homogenously enhanced with Gd-DTPA. Surgery via the trans-cranial approach revealed a pinkish and elastic-hard tumor. Total resection was successfully performed. The hematoxilyn-eosin staining of the surgical specimen showed a dense infiltrate of lymphocytes, which were composed predominantly of small lymphocytes, centrocyte-like cells, monocytoid cells, and occasionally transformed lymphocytes. The immunohistochemical findings for CD20, CD3, UCHL-1, CD23, CD5, cyclinD1, and bcl-2 were compatible with Mucosa Associated Lymphoid Tissue (MALT)-type lymphoma. The patient received local radiation therapy (30 Gy/15 fractions). She remained in complete clinical remission of the disease about one and a half years after treatment.
一名72岁女性因左上外侧眼睑肿物就诊。磁共振成像显示左泪腺有一个边界清晰的肿块。该肿瘤在T1加权像和T2加权像上均呈等信号,注射钆喷酸葡胺后均匀强化。经颅手术显示肿瘤呈粉红色,质地硬且有弹性。成功进行了全切术。手术标本苏木精-伊红染色显示淋巴细胞密集浸润,主要由小淋巴细胞、中心细胞样细胞、单核样细胞组成,偶尔可见转化淋巴细胞。CD20、CD3、UCHL-1、CD23、CD5、细胞周期蛋白D1和bcl-2的免疫组化结果符合黏膜相关淋巴组织(MALT)型淋巴瘤。患者接受了局部放疗(30 Gy/15次分割)。治疗后约一年半,她仍处于疾病完全临床缓解状态。