二维和三维超声检查在正常胎儿肺容积测量中的比较。

Comparison of two- and three-dimensional ultrasonography in lung volume measurement of normal fetuses.

作者信息

Araujo Júnior Edward, Nardozza Luciano Marcondes Machado, Rodrigues Pires Claudio, Filho Hélio Antonio Guimarães, Moron Antonio Fernandes

机构信息

Department of Obstetrics, Sao Paulo's Federal University (Unifesp/EPM), Sao Paulo, SP, Brazil.

出版信息

J Perinat Med. 2007;35(5):415-21. doi: 10.1515/JPM.2007.073.

DOI:10.1515/JPM.2007.073

PMID:17504009

Abstract

AIM

The purpose of this study was to compare the two- and three-dimensional methods for measuring fetal lung volume of normal fetuses.

METHODS

A cross-sectional study was performed with 51 normal pregnant women between 20 and 35 weeks. The ellipsoid formula (XYZ*0.52) was used for volume calculation with the two-dimensional (2D) method. With the VOCAL (Virtual Organ Computer-aided Analysis) method, a rotation angle of 30 degrees was used. Intraclass correlation coefficient (ICC), paired Student's t-test and Bland-Altman plots were used to compare the techniques. To calculate the intraobserver variability we used the ICC and compared the means between the two measures using the paired Student's p-test.

RESULTS

VOCAL and 2D methods were highly correlated (ICC=0.919 and 0.873 for the right and left lungs, respectively), however, there was a disagreement. The fetal lung volume means calculated by the 2D method were always overestimated in relation to the means obtained by the VOCAL, for the right lung (24.02 mL x 19.15 mL; P<0.001), as well as for the left (16.03 mL x 13.77 mL; P=0.002). As for the intraobserver variability, a good reproducibility was observed for the volume measurement of the left lung by the 2D technique (mean=0.40 mL; P=0.57) and by the VOCAL (mean=-0.22 mL; P=0.63). The 2D method, however, presented low reproducibility for the right lung (mean=1.73 mL; P=0.31).

CONCLUSION

The two-dimensional method had low agreement and low reproducibility in relation to the three-dimensional method for measurement of fetal lung volume in normal fetuses.

摘要

目的

本研究旨在比较测量正常胎儿肺容积的二维和三维方法。

方法

对51名孕20至35周的正常孕妇进行横断面研究。二维（2D）方法使用椭球体公式（XYZ*0.52）计算容积。采用VOCAL（虚拟器官计算机辅助分析）方法时，旋转角度为30度。使用组内相关系数（ICC）、配对t检验和Bland-Altman图比较这些技术。为计算观察者内变异性，我们使用ICC并通过配对t检验比较两次测量的均值。

结果

VOCAL和2D方法高度相关（右肺和左肺的ICC分别为0.919和0.873），然而，存在差异。二维方法计算的胎儿肺容积均值相对于VOCAL获得的均值总是高估，右肺（24.02 mL对19.15 mL；P<0.001）以及左肺（16.03 mL对13.77 mL；P=0.002）均如此。至于观察者内变异性，二维技术对左肺容积测量具有良好的可重复性（均值=0.40 mL；P=0.57），VOCAL方法对左肺也具有良好的可重复性（均值=-0.22 mL；P=0.63）。然而，二维方法对右肺的可重复性较低（均值=1.73 mL；P=0.31）。