通过插入诱变在乳酸乳球菌中产生羊毛硫抗生素抗性。
Insertional mutagenesis to generate lantibiotic resistance in Lactococcus lactis.
作者信息
Guinane Caitriona M, Cotter Paul D, Lawton Elaine M, Hill Colin, Ross R Paul
机构信息
Department of Microbiology, University College Cork, Cork, Ireland.
出版信息
Appl Environ Microbiol. 2007 Jul;73(14):4677-80. doi: 10.1128/AEM.02351-06. Epub 2007 May 25.
Abstract
While the potential emergence of food spoilage and pathogenic bacteria with resistance to lantibiotics is a concern, the creation of derivatives of starter cultures and adjuncts that can grow in the presence of these antimicrobials may have applications in food fermentations. Here a bank of Lactococcus lactis IL1403 mutants was created and screened, and a number of novel genetic loci involved in lantibiotic resistance were identified.
摘要
虽然出现对羊毛硫抗生素具有抗性的食品腐败菌和病原菌令人担忧，但开发能够在这些抗菌剂存在的情况下生长的发酵剂培养物和添加剂衍生物可能在食品发酵中具有应用价值。在此，构建并筛选了一组乳酸乳球菌IL1403突变体库，鉴定出了一些与羊毛硫抗生素抗性相关的新基因座。
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