Kato Taro, Ohtani-Kaneko Ritsuko, Shiga Takashi
Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.
Neurosci Res. 2007 Aug;58(4):402-5. doi: 10.1016/j.neures.2007.04.010. Epub 2007 Apr 29.
In the dorsal horn of the chick embryo spinal cord, extracellular signal-regulated kinase (ERK) was phosphorylated transiently during embryonic days 6 and 9. Co-culture studies suggested that dorsal root ganglion (DRG) activated ERK in the dorsal horn. Brain-derived neurotrophic factor (BDNF) activated ERK in the dorsal horn, and anti-BDNF blocked the DRG-induced ERK activation. These results suggest roles of BDNF in the DRG-induced ERK activation in the embryonic dorsal horn.
在鸡胚脊髓的背角中，细胞外信号调节激酶（ERK）在胚胎第6天和第9天期间短暂磷酸化。共培养研究表明，背根神经节（DRG）激活了背角中的ERK。脑源性神经营养因子（BDNF）激活了背角中的ERK，而抗BDNF则阻断了DRG诱导的ERK激活。这些结果表明BDNF在胚胎背角中DRG诱导的ERK激活中发挥作用。
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