Okio Hino, Kazu Shiomi, Masahiro Maeda
Department of Pathology and Oncology, Juntendo University School of Medicine, 2-1-1 Hongo, Tokyo, Japan.
Cancer Sci. 2007 Aug;98(8):1147-51. doi: 10.1111/j.1349-7006.2007.00520.x. Epub 2007 May 25.
Mesothelioma is an aggressive tumor arising from the mesothelium, and is usually associated with previous exposure to asbestos. The incubation period of asbestos-related mesothelioma is estimated to be approximately 30-40 years. Once mesothelioma has occurred, there is no effective treatment. So, identification of tumor markers and a method for early diagnosis using such markers are urgently needed. Recently, several enzyme-linked immunosorbent assay systems for Erc/mesothelin have been developed, the reported usefulness of which has been assessed and demonstrated as a diagnostic tool. Asbestos-related mesothelioma should be ascribed as a typical environmental carcinogen. In this review, we will present asbestos-related mesothelioma for the study of problems in environmental carcinogenesis.
间皮瘤是一种起源于间皮的侵袭性肿瘤,通常与既往接触石棉有关。石棉相关间皮瘤的潜伏期估计约为30至40年。一旦发生间皮瘤,就没有有效的治疗方法。因此,迫切需要鉴定肿瘤标志物以及使用此类标志物进行早期诊断的方法。最近,已经开发了几种针对Erc/间皮素的酶联免疫吸附测定系统,其报告的实用性已作为一种诊断工具进行了评估和证明。石棉相关间皮瘤应被视为典型的环境致癌物。在本综述中,我们将介绍石棉相关间皮瘤,以研究环境致癌中的问题。