脊柱关节炎中肠道与关节的密切关系。
The intimate relationship between gut and joint in spondyloarthropathies.
作者信息
Jacques Peggy, Mielants Herman, Coppieters Ken, De Vos Martine, Elewaut Dirk
机构信息
Department of Internal Medicine, Rheumatology, University Hospital of Ghent, Ghent, Belgium.
出版信息
Curr Opin Rheumatol. 2007 Jul;19(4):353-7. doi: 10.1097/BOR.0b013e328133f59f.
PURPOSE OF REVIEW
The aim of this article is to highlight recent progress in the combined joint and gut disease in spondyloarthropathies.
RECENT FINDINGS
A set of genes has been identified that are differentially expressed in the colon of spondyloarthropathy and Crohn's disease patients. Reduction of human leukocyte antigen B27 (HLA B27) misfolding by additional beta2-microglobulin in HLA B27 transgenic rats unexpectedly increased disease severity, with more similarities to spondyloarthropathies. By contrast, colitis disappeared.
SUMMARY
Human genomic studies combined with animal model research provide new clues concerning the common pathogenesis of spondyloarthropathy and Crohn's disease, further substantiating the unique relationship between gut and joint inflammation.
综述目的
本文旨在强调脊柱关节炎中关节与肠道联合疾病的近期进展。
近期发现
已鉴定出一组在脊柱关节炎患者和克罗恩病患者结肠中差异表达的基因。在 HLA B27 转基因大鼠中，额外的β2-微球蛋白减少 HLA B27 错误折叠意外地增加了疾病严重程度，与脊柱关节炎更相似。相比之下，结肠炎消失了。
总结
人类基因组研究与动物模型研究相结合，为脊柱关节炎和克罗恩病的共同发病机制提供了新线索，进一步证实了肠道与关节炎症之间的独特关系。
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