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采用相控阵通道进行聚焦式耳蜗内电刺激。

Focused intracochlear electric stimulation with phased array channels.

作者信息

van den Honert Chris, Kelsall David C

机构信息

Cochlear Americas, 400 Inverness Parkway, Englewood, Colorado 80112, USA.

出版信息

J Acoust Soc Am. 2007 Jun;121(6):3703-16. doi: 10.1121/1.2722047.

Abstract

A method is described for producing focused intracochlear electric stimulation using an array of N electrodes. For each electrode site, N weights are computed that define the ratios of positive and negative electrode currents required to produce cancellation of the voltage within scala tympani at all of the N-1 other sites. Multiple sites can be stimulated simultaneously by superposition of their respective current vectors. The method allows N independent stimulus waveforms to be delivered to each of the N electrode sites without spatial overlap. Channel interaction from current spread associated with monopolar stimulation is substantially eliminated. The method operates by inverting the spread functions of individual monopoles as measured with the other electrodes. The method was implemented and validated with data from three human subjects implanted with 22-electrode perimodiolar arrays. Results indicate that (1) focusing is realizable with realistic precision; (2) focusing comes at the cost of increased total stimulation current; (3) uncanceled voltages that arise beyond the ends of the array are weak except when stimulating the two end channels; and (4) close perimodiolar positioning of the electrodes may be important for minimizing stimulation current and sensitivity to measurement errors.

摘要

描述了一种使用N个电极阵列产生聚焦式耳蜗内电刺激的方法。对于每个电极位点,计算N个权重,这些权重定义了在其他N - 1个位点的鼓阶内产生电压抵消所需的正负极电流之比。通过叠加各自的电流矢量,可以同时刺激多个位点。该方法允许将N个独立的刺激波形输送到N个电极位点中的每一个,而不会产生空间重叠。与单极刺激相关的电流扩散引起的通道相互作用被基本消除。该方法通过反转用其他电极测量的单个单极子的扩散函数来运行。该方法已通过对三名植入了22电极蜗周阵列的人类受试者的数据进行实施和验证。结果表明:(1) 可以以实际精度实现聚焦;(2) 聚焦是以增加总刺激电流为代价的;(3) 除了刺激两个末端通道时,在阵列末端之外出现的未抵消电压很弱;(4) 电极的紧密蜗周定位对于最小化刺激电流和对测量误差的敏感性可能很重要。

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