Genetic engineering cures mice of neurological deficits: prospects for treating Angelman syndrome.
作者信息
Elgersma Ype
出版信息
Pharmacogenomics. 2007 Jun;8(6):539-41. doi: 10.2217/14622416.8.6.539.
PMID:17559342
Abstract
摘要
相似文献
1
Genetic engineering cures mice of neurological deficits: prospects for treating Angelman syndrome.
Pharmacogenomics. 2007 Jun;8(6):539-41. doi: 10.2217/14622416.8.6.539.
2
Modelling brain diseases in mice: the challenges of design and analysis.
Nat Rev Genet. 2003 Apr;4(4):296-307. doi: 10.1038/nrg1045.
3
Neurodevelopmental disorders. Unmuting Ube3a in mice alleviates Angelman syndrome.神经发育障碍。使小鼠体内的泛素蛋白连接酶E3A基因（Ube3a）恢复活性可缓解天使综合征。
Nat Rev Neurol. 2015 Feb;11(2):66. doi: 10.1038/nrneurol.2014.240. Epub 2014 Dec 16.
4
Detection of a novel familial deletion of four genes between BP1 and BP2 of the Prader-Willi/Angelman syndrome critical region by oligo-array CGH in a child with neurological disorder and speech impairment.通过寡核苷酸阵列比较基因组杂交技术在一名患有神经障碍和言语障碍的儿童中检测到普拉德-威利/安吉尔曼综合征关键区域BP1和BP2之间四个基因的新型家族性缺失。
Cytogenet Genome Res. 2007;116(1-2):135-40. doi: 10.1159/000097433.
5
Neurodevelopmental disorders. New hope for a devastating neurological disorder.
Science. 2011 Dec 23;334(6063):1615. doi: 10.1126/science.334.6063.1615.
6
[Brain abnormalities in genomic imprinting diseases].
No To Shinkei. 2001 May;53(5):437-43.
7
New technologies deliver in treating neurological diseases.新技术在治疗神经疾病方面发挥作用。
Nat Med. 2004 Dec;10(12):1267. doi: 10.1038/nm1204-1267a.
8
Prospects of treating neurological diseases by gene therapy.基因治疗在治疗神经疾病方面的前景。
Curr Opin Investig Drugs. 2007 Jan;8(1):34-40.
9
Parsing out reality from genetically engineered mouse models of neurologic diseases.从神经疾病的基因工程小鼠模型中剖析现实情况。
Brain Res Bull. 2012 May 1;88(1):1-2. doi: 10.1016/j.brainresbull.2012.04.004. Epub 2012 Apr 7.
10
Adult dysmorphology: perspectives on approach to diagnosis and care.
Am J Med Genet C Semin Med Genet. 2007 Aug 15;145C(3):227-9. doi: 10.1002/ajmg.c.30134.
引用本文的文献
1
Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome.泛素连接酶 E3A 基因完全缺失的 Angelman 综合征大鼠模型中的转化结果。
Transl Psychiatry. 2020 Jan 27;10(1):39. doi: 10.1038/s41398-020-0720-2.
Zotero 插件