从马（纯种马）初乳中获得的三种中性寡糖的化学结构。
Chemical structures of three neutral oligosaccharides obtained from horse (thoroughbred) colostrum.
作者信息
Urashima T, Saito T, Kimura T
机构信息
Laboratory of Bioindustrial Food Chemistry, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
出版信息
Comp Biochem Physiol B. 1991;100(1):177-83. doi: 10.1016/0305-0491(91)90103-k.
PMID:1756618
Abstract
- Three neutral oligosaccharides were obtained from horse colostrum by ion-exchange, activated charcoal column and preparative paper chromatographies. 2. The following structures were elucidated by methanolysis, methylation analysis and 75 MHz 13C-NMR spectroscopy; Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc (HM-3a), Gal beta 1-4GlcNAc beta 1-6Gal beta 1-4Glc (HM-3b) and Gal beta 1-4GlcNAc beta 1-3[Gal beta 1-4GlcNAc beta 1-6]Gal beta 1-4Glc (HM-5). 3. HM-3a and HM-5 have been found in human milk, named as lacto-N-neotetraose and lacto-N-neohexaose, respectively. HM-3b has been isolated from goat milk. 4. An homology and heterogeneity were assumed among the following animal species' milk oligosaccharides: horse, human, goat and tammar wallaby.
摘要
- 通过离子交换、活性炭柱色谱和制备型纸色谱法从马初乳中获得了三种中性寡糖。2. 通过甲醇解、甲基化分析和75兆赫的碳-13核磁共振光谱法阐明了以下结构：β-D-半乳糖-(1→4)-N-乙酰-β-D-葡萄糖胺-(1→3)-β-D-半乳糖-(1→4)-葡萄糖（HM-3a）、β-D-半乳糖-(1→4)-N-乙酰-β-D-葡萄糖胺-(1→6)-β-D-半乳糖-(1→4)-葡萄糖（HM-3b）和β-D-半乳糖-(1→4)-N-乙酰-β-D-葡萄糖胺-(1→3)[β-D-半乳糖-(1→4)-N-乙酰-β-D-葡萄糖胺-(1→6)]-β-D-半乳糖-(1→4)-葡萄糖（HM-5）。3. HM-3a和HM-5已在人乳中发现，分别命名为乳糖-N-新四糖和乳糖-N-新六糖。HM-3b已从山羊乳中分离出来。4. 假定以下动物物种的乳寡糖之间存在同源性和异质性：马、人、山羊和沙袋鼠。
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