Chen Li-Chia, Ashcroft Darren M, Elliott Rachel A
School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, 1st Floor, Stopford Building, Oxford Road, Manchester, M13 9PT, UK.
Pharm World Sci. 2007 Dec;29(6):661-70. doi: 10.1007/s11096-007-9125-z. Epub 2007 Jun 14.
To explore pharmacists' perceptions on the use of economic evaluations in decision-making within Medicine Management Committees (MMCs), identify factors that influence the uptake of economic evidence and examine the usefulness of different presentations of economic evidence.
This two-stage qualitative study was carried out in July and August 2004 in two hospitals in northwest England. First, a researcher observed the decision-making process at two MMCs. Handwritten notes were made during observation, which were later transcribed. Subsequently, in-depth semi-structured interviews were conducted with a purposive sample of pharmacists involved in the MMCs. The interviews explored pharmacists' views on the usefulness of economic evaluations in decision-making, the factors influencing the uptake of economic evidence by the MMCs, and the optimal presentation of economic results. The interviews were audiotaped and transcribed verbatim. All the transcribed data were thematically analysed using the constant comparison approach.
In all, six new drug applications were observed and ten pharmacists were interviewed. Pharmacists were observed to play an important role in decisions about drug formularies in hospitals. Although interviewees considered that timely economic evaluations would be useful in reviewing new medicines, the actual use of economic evidence in decision-making within MMCs was limited. The barriers to using economic evaluations included pharmacists' lack of initiative to search for and difficulty in understanding economic evaluations, and the perceived availability, credibility and transferability of economic studies. However, the main barrier to implementing economic evidence was the decision makers' concern about the impact of the medicines on the hospitals' drug budgets. Interviewees felt that they understood and trusted disaggregated economic results better than aggregated ones.
This study found the use of economic evidence in decision-making at both MMCs was limited. To improve the usefulness of economic evaluations in MMCs, members of MMCs will need more training in accessing, understanding and appraising economic evidence; researchers need to improve the credibility and transferability of economic studies, and present the results in clear and understandable ways. However, due to the restricted focus of local, short-term drug budgets, evidence-based decision-making remains a challenge for local MMCs.
探讨药剂师对药物管理委员会(MMCs)决策过程中使用经济评估的看法,确定影响经济证据采用的因素,并检验经济证据不同呈现方式的有用性。
这项两阶段的定性研究于2004年7月和8月在英格兰西北部的两家医院进行。首先,一名研究人员观察了两个MMCs的决策过程。观察期间做了手写笔记,随后进行了转录。随后,对参与MMCs的药剂师进行了有目的抽样的深入半结构化访谈。访谈探讨了药剂师对经济评估在决策中的有用性的看法、影响MMCs采用经济证据的因素以及经济结果的最佳呈现方式。访谈进行了录音并逐字转录。所有转录数据均采用持续比较法进行主题分析。
总共观察了6项新药申请,并采访了10名药剂师。观察到药剂师在医院药品处方决策中发挥着重要作用。尽管受访者认为及时的经济评估对新药审查有用,但MMCs决策中经济证据的实际使用有限。使用经济评估的障碍包括药剂师缺乏主动寻找经济评估的积极性以及理解经济评估的困难,以及经济研究的可获得性、可信度和可转移性。然而,实施经济证据的主要障碍是决策者对药品对医院药品预算的影响的担忧。受访者认为他们对分类的经济结果比汇总的经济结果理解和信任程度更高。
本研究发现,MMCs在决策中对经济证据的使用有限。为提高经济评估在MMCs中的有用性,MMCs成员需要在获取、理解和评估经济证据方面接受更多培训;研究人员需要提高经济研究的可信度和可转移性,并以清晰易懂的方式呈现结果。然而,由于地方短期药品预算的重点有限,基于证据的决策对地方MMCs来说仍然是一项挑战。