Planchamp Corinne, Gex-Fabry Marianne, Becker Christoph D, Pastor Catherine M
Laboratoire de Physiopathologie Hépatique et Imagerie Moléculaire, and Département de Psychiatrie, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
Invest Radiol. 2007 Jul;42(7):513-21. doi: 10.1097/RLI.0b013e318036b450.
To quantify the hepatic transport of the hepatobiliary contrast agent gadobenate dimeglumine (Gd-BOPTA) in rats with biliary cirrhosis of various severity degrees from magnetic resonance (MR) signal intensities using a population pharmacokinetic approach.
MR signal intensity was recorded during the Gd-BOPTA perfusion of normal and cirrhotic isolated rat livers. Similar experiments were conducted with Gd-labeled Gd-BOPTA to quantify Gd-BOPTA content in liver, bile, and perfusate. All experimental data were analyzed together according to a population pharmacokinetic approach.
A 6-compartment model developed from the radioactivity data adequately fit all MRI data when 4 image parameters were added to describe the relationship between the amount of contrast agent and the signal intensity. The model showed that entry of Gd-BOPTA into hepatocytes was decreased in cirrhotic livers when compared to normal livers.
Although the MR signal intensity is similar in normal and cirrhotic livers, the population pharmacokinetic approach developed in this study shows a decreased entry of Gd-BOPTA into cirrhotic hepatocytes.
采用群体药代动力学方法，通过磁共振（MR）信号强度对不同严重程度胆汁性肝硬化大鼠肝胆造影剂钆贝葡胺（Gd - BOPTA）的肝脏转运进行定量分析。
在正常和肝硬化离体大鼠肝脏的Gd - BOPTA灌注过程中记录MR信号强度。用Gd标记的Gd - BOPTA进行类似实验，以定量肝脏、胆汁和灌注液中Gd - BOPTA的含量。根据群体药代动力学方法对所有实验数据进行综合分析。
当添加4个图像参数来描述造影剂含量与信号强度之间的关系时，由放射性数据建立的六室模型能很好地拟合所有MRI数据。该模型表明，与正常肝脏相比，肝硬化肝脏中Gd - BOPTA进入肝细胞的量减少。
尽管正常肝脏和肝硬化肝脏的MR信号强度相似，但本研究建立的群体药代动力学方法显示Gd - BOPTA进入肝硬化肝细胞的量减少。
