渗透屏障稳态的调节。
The regulation of permeability barrier homeostasis.
作者信息
Feingold Kenneth R, Schmuth Matthias, Elias Peter M
机构信息
Department of Medicine, University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, California 94121, USA.
出版信息
J Invest Dermatol. 2007 Jul;127(7):1574-6. doi: 10.1038/sj.jid.5700774.
Disruption of the permeability barrier stimulates a repair response that leads to the restoration of barrier function. Previous studies demonstrated that changes in ions, particularly calcium, and cytokines are positive signals, whereas serine protease activation of proteinase-activated receptor 2 is a negative signal regulating barrier recovery. Ikeyama and colleagues provide data that the nitric oxide signaling pathway also regulates barrier homeostasis.
通透性屏障的破坏会刺激一种修复反应，从而导致屏障功能的恢复。先前的研究表明，离子尤其是钙的变化以及细胞因子是正向信号，而蛋白酶激活受体2的丝氨酸蛋白酶激活是调节屏障恢复的负向信号。池山及其同事提供的数据表明，一氧化氮信号通路也调节屏障的稳态。
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