两例同胞新生儿短暂性甲状旁腺功能减退症揭示母亲的正常血钙性甲状旁腺功能亢进症

Transient neonatal hypoparathyroidism in two siblings unmasking maternal normocalcemic hyperparathyroidism.

作者信息

Poomthavorn Preamrudee, Ongphiphadhanakul Boonsong, Mahachoklertwattana Pat

机构信息

Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Bangkok, 10400, Thailand.

出版信息

Eur J Pediatr. 2008 Apr;167(4):431-4. doi: 10.1007/s00431-007-0528-6. Epub 2007 Jun 15.

DOI:10.1007/s00431-007-0528-6

PMID:17569990

Abstract

Hypoparathyroidism is one of the recognized causes of late-onset neonatal hypocalcemia. Maternal hypercalcemic hyperparathyroidism has been shown to suppress fetal parathyroid glands, causing transient neonatal hypoparathyroidism. We report two siblings (6 years apart) with transient hypoparathyroidism presented with hypocalcemic seizures during the first 2 weeks of life. Subsequent investigation revealed an unrecognized normocalcemic hyperparathyroidism with nephrocalcinosis in the mother. Maternal hyperparathyroidism was caused by two parathyroid adenomas. In conclusion, our report highlights the importance of careful evaluation of neonatal hypoparathyroidism in uncovering an unrecognized, asymptomatic hyperparathyroidism in the mother.

摘要

甲状旁腺功能减退是晚发性新生儿低钙血症的公认病因之一。已证实母亲的高钙血症性甲状旁腺功能亢进会抑制胎儿甲状旁腺，导致短暂性新生儿甲状旁腺功能减退。我们报告了两名（相差6岁）患有短暂性甲状旁腺功能减退的同胞，他们在出生后的前2周出现了低钙血症性惊厥。随后的检查发现母亲存在未被识别的正常血钙性甲状旁腺功能亢进伴肾钙质沉着症。母亲的甲状旁腺功能亢进是由两个甲状旁腺腺瘤引起的。总之，我们的报告强调了仔细评估新生儿甲状旁腺功能减退对于发现母亲未被识别的无症状甲状旁腺功能亢进的重要性。