基于双重作用的抗菌剂方法。

Dual action-based approaches to antibacterial agents.

作者信息

Bremner John B, Ambrus Joseph I, Samosorn Siritron

机构信息

Department of Chemistry, University of Wollongong, Wollongong, NSW, 2522, Australia.

出版信息

Curr Med Chem. 2007;14(13):1459-77. doi: 10.2174/092986707780831168.

DOI:10.2174/092986707780831168

PMID:17584056

Abstract

This review collates and analyses recent work done on dual action approaches to tackling the mounting health problem of resistance by human pathogenic bacteria to antibacterial agents. In particular the areas reviewed include the use of two drugs in combination, dual action prodrugs, and dual action drugs (or hybrid drugs).

摘要

本综述整理并分析了近期在应对人类病原菌对抗菌剂耐药性这一日益严重的健康问题时采用的双重作用方法的相关研究工作。具体而言，所综述的领域包括两种药物联合使用、双重作用前药以及双重作用药物（或杂合药物）。