外周T细胞中的生死

Life and death in peripheral T cells.

作者信息

Krammer Peter H, Arnold Rüdiger, Lavrik Inna N

机构信息

Tumour Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

出版信息

Nat Rev Immunol. 2007 Jul;7(7):532-42. doi: 10.1038/nri2115.

DOI:10.1038/nri2115

PMID:17589543

Abstract

During the course of an immune response, antigen-reactive T cells clonally expand and then are removed by apoptosis to maintain immune homeostasis. Life and death of T cells is determined by multiple factors, such as T-cell receptor triggering, co-stimulation or cytokine signalling, and by molecules, such as caspase-8 (FLICE)-like inhibitory protein (FLIP) and haematopoietic progenitor kinase 1 (HPK1), which regulate the nuclear factor-kappaB (NF-kappaB) pathway. Here, we discuss the concepts of activation-induced cell death (AICD) and activated cell-autonomous death (ACAD) in the regulation of life and death in T cells.

摘要

在免疫反应过程中，抗原反应性T细胞发生克隆性扩增，然后通过凋亡被清除以维持免疫稳态。T细胞的生死由多种因素决定，如T细胞受体触发、共刺激或细胞因子信号传导，以及由调节核因子-κB（NF-κB）途径的分子，如半胱天冬酶-8（FLICE）样抑制蛋白（FLIP）和造血祖细胞激酶1（HPK1）决定。在此，我们讨论激活诱导的细胞死亡（AICD）和激活的细胞自主死亡（ACAD）在T细胞生死调节中的概念。