现代宫颈癌筛查。HPV预防性疫苗的前景。

Modern screening in cervical cancer. Perspectives of HPV prophylactic vaccines.

作者信息

Vlădăreanu R, Andrei Cr

机构信息

Obstetrics and Gynecology Department, Elias Univesitary Emergency Hospital, Bucucureşti.

出版信息

Rev Med Chir Soc Med Nat Iasi. 2007 Jan-Mar;111(1):144-54.

PMID:17595860

Abstract

Despite the tremendous progress made along several different lines of research, cervical cancer has not has been overcome. The presence or the absence of the HR-HPV infection defines new possible approaches to screen and prevent cervical cancer. The aim of this review is to summarize the mechanisms that contribute to HPV-mediated cervical carcinogenesis, to present the modern screening in cervical cancer (liquid-based cytology, liquid-based hybridization, PCR-based assays) and also the beginning of the HPV vaccine era.

摘要

尽管在多个不同研究领域取得了巨大进展，但宫颈癌仍未被攻克。高危型人乳头瘤病毒（HR-HPV）感染的有无为宫颈癌的筛查和预防提供了新的可能途径。本综述的目的是总结HPV介导的宫颈癌发生机制，介绍宫颈癌的现代筛查方法（液基细胞学检查、液基杂交、基于聚合酶链反应的检测方法）以及HPV疫苗时代的开端。