Nouraei S A Reza, Maani Tareq, Hajioff Daniel, Saleh Hesham A, Mackay Ian S
Department of Otolaryngology, Charing Cross Hospital, London, United Kingdom.
Laryngoscope. 2007 Aug;117(8):1452-6. doi: 10.1097/MLG.0b013e318065b86f.
OBJECTIVE/HYPOTHESIS: To evaluate the efficacy of surgical sphenopalatine artery occlusion (SAO) for treating intractable epistaxis, and identify factors associated with long-term success or failure of this procedure.
A retrospective chart review of patients undergoing SAO surgery between January 1995 and 2005 was undertaken. Clinical and hematologic information, preoperative and surgical care, short-term complications, and long-term outcome were recorded. Binary logistic regression was used to identify risk factors for early re-bleeding, and log-rank statistics with Cox regression were used to identify risk factors for long-term operative failure.
Sixty-seven patients underwent 71 SAO operations. The average age at surgery was 56 +/- 18 years. Thirty percent of patients were being treated for hypertension, 19% were taking aspirin, and 11% were anticoagulated with warfarin. Many patients (46%) had >72 hours of epistaxis before admission, and 25% required preoperative transfusion. There were 13 (19%) bilateral procedures, six patients underwent concomitant anterior ethmoid artery occlusion, and 12 patients had concomitant septoplasty. Eight patients had significant early re-bleeding. Platelet levels on admission and not using diathermy to occlude the sphenopalatine artery were independent risk factors for this (P values .03, and .02, respectively). Not using diathermy was also an independent risk factor for late operative failure on Cox regression, reducing the mean re-intervention-free interval from 94 +/- 7 to 32 +/- 7 months (P < .007; hazard ratio 6.4; 95% confidence interval 1.7-24.9).
SAO is an effective operation and, in trained hands, an appropriate first-line procedure for treating intractable epistaxis. Use of diathermy significantly improves the short- and long-term outcome of this surgery.
目的/假设:评估蝶腭动脉闭塞术(SAO)治疗难治性鼻出血的疗效,并确定与该手术长期成功或失败相关的因素。
对1995年1月至2005年间接受SAO手术的患者进行回顾性病历审查。记录临床和血液学信息、术前和手术护理、短期并发症及长期预后。采用二元逻辑回归确定早期再出血的危险因素,采用Cox回归的对数秩统计确定长期手术失败的危险因素。
67例患者接受了71次SAO手术。手术平均年龄为56±18岁。30%的患者因高血压接受治疗,19%的患者服用阿司匹林,11%的患者使用华法林抗凝。许多患者(46%)入院前鼻出血超过72小时,25%的患者术前需要输血。有13例(19%)为双侧手术,6例患者同时进行了筛前动脉闭塞术,12例患者同时进行了鼻中隔成形术。8例患者出现严重早期再出血。入院时血小板水平及未使用透热法闭塞蝶腭动脉是其独立危险因素(P值分别为0.03和0.02)。未使用透热法也是Cox回归中晚期手术失败的独立危险因素,使平均无再次干预间隔从94±7个月缩短至32±7个月(P<0.007;风险比6.4;95%置信区间1.7 - 24.9)。
SAO是一种有效的手术方法,对于训练有素的医生来说,是治疗难治性鼻出血的合适一线手术。使用透热法可显著改善该手术的短期和长期预后。