Ichimaru M, Tomonaga M, Amenomori T, Matsuo T
Department of Hematology, Nagasaki University School of Medicine, Japan.
J Radiat Res. 1991 Mar;32 Suppl:162-7. doi: 10.1269/jrr.32.supplement_162.
Characteristic features of leukemia among atomic bomb survivors were studied. The ratio of a single leukemia type to all leukemias was highest for CML in Hiroshima, and the occurrence of CML was thought to be most characteristic for atomic bomb radiation induced leukemia. In the distribution of AML subtypes of FAB classification, there was no M3 cases in 1Gy or more group, although several atypical AML cases of survivors were observed. Chromosome study was conducted using colony forming cells induced by hemopoietic stem cells of peripheral blood of proximal survivors. Same chromosome aberrations were observed in colony forming cells and peripheral blood of proximal survivors.
对原子弹爆炸幸存者白血病的特征进行了研究。在广岛,慢性粒细胞白血病(CML)在单一白血病类型与所有白血病中的比例最高,CML的发生被认为是原子弹辐射诱发白血病最具特征性的表现。在FAB分类的急性髓系白血病(AML)亚型分布中,1Gy及以上剂量组未出现M3病例,不过观察到了几名幸存者的非典型AML病例。使用近距幸存者外周血造血干细胞诱导的集落形成细胞进行了染色体研究。在近距幸存者的集落形成细胞和外周血中观察到了相同的染色体畸变。