滤泡性淋巴瘤中白细胞介素-21受体的高表达及白细胞介素-21诱导的细胞凋亡

High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma.

作者信息

Akamatsu Norihiko, Yamada Yasuaki, Hasegawa Hiroo, Makabe Koki, Asano Ryutaro, Kumagai Izumi, Murata Ken, Imaizumi Yoshitaka, Tsukasaki Kunihiro, Tsuruda Kazuto, Sugahara Kazuyuki, Atogami Sunao, Yanagihara Katsunori, Kamihira Shimeru

机构信息

Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.

出版信息

Cancer Lett. 2007 Oct 28;256(2):196-206. doi: 10.1016/j.canlet.2007.06.001. Epub 2007 Jul 10.

DOI:10.1016/j.canlet.2007.06.001

PMID:17624663

Abstract

We surveyed IL-21 receptor (IL-21R) in leukemia and lymphoma and found that follicular lymphoma cells showed exceptionally high IL-21R expression. Notably, IL-21 showed divergent effects depending on the cell origin: growth stimulation in Burkitt lymphoma cell lines and adult T cell leukemia/lymphoma cell lines but induction of apoptosis in B lymphoma cell lines with t(14;18)(q32;q21), a marker karyotype of follicular lymphoma. IL-21 activated caspase-8 and -3 and reduced mitochondrial membrane potential. More importantly, IL-21 decreased Bcl-2 expression but increased Bax expression. These results support a new therapeutic approach using the IL-21/IL-21R system in follicular lymphoma.

摘要

我们对白血病和淋巴瘤中的白细胞介素-21受体（IL-21R）进行了研究，发现滤泡性淋巴瘤细胞呈现出异常高的IL-21R表达。值得注意的是，IL-21根据细胞来源表现出不同的作用：对伯基特淋巴瘤细胞系和成人T细胞白血病/淋巴瘤细胞系有生长刺激作用，但对具有t(14;18)(q32;q21)（滤泡性淋巴瘤的标志性核型）的B淋巴瘤细胞系有诱导凋亡作用。IL-21激活了半胱天冬酶-8和-3，并降低了线粒体膜电位。更重要的是，IL-21降低了Bcl-2的表达，但增加了Bax的表达。这些结果支持在滤泡性淋巴瘤中使用IL-21/IL-21R系统的一种新的治疗方法。