Toll样受体2（TLR2）基因多态性与2型单纯疱疹病毒感染患者病毒脱落增加及皮损发生率升高相关。

Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection.

作者信息

Bochud Pierre-Yves, Magaret Amalia S, Koelle David M, Aderem Alan, Wald Anna

机构信息

Institute for Systems Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98103, USA.

出版信息

J Infect Dis. 2007 Aug 15;196(4):505-9. doi: 10.1086/519693. Epub 2007 Jun 29.

DOI:10.1086/519693

PMID:17624834

Abstract

Clinical and virologic manifestations of genital herpes simplex virus type 2 (HSV-2) infection vary widely. We examined frequencies of single-nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) 2, 3, 4, and 9 in a prospective cohort of 128 HSV-2-infected persons whose viral shedding and lesion frequency was measured by daily sampling from genital secretions. Two TLR2 haplotypes (2 and 4) were associated with increased lesional (P=.008 and P=.03) and shedding (P=.02 and P=.001) rates. An SNP in haplotype 2 (-15607A/G) was also associated with shedding (P=.01) and lesional (P=.008) rates. Polymorphisms in TLR2 may be in part responsible for differences in the severity of HSV-2 infection.

摘要

2型单纯疱疹病毒（HSV-2）感染的临床和病毒学表现差异很大。我们在一个由128名HSV-2感染者组成的前瞻性队列中，检测了Toll样受体（TLR）2、3、4和9中单核甘酸多态性（SNP）的频率，该队列通过每天采集生殖器分泌物样本测量病毒脱落情况和损伤频率。两种TLR2单倍型（2型和4型）与更高的损伤率（P=0.008和P=0.03）和病毒脱落率（P=0.02和P=0.001）相关。单倍型2中的一个SNP（-15607A/G）也与病毒脱落率（P=0.01）和损伤率（P=0.008）相关。TLR2中的多态性可能部分导致了HSV-2感染严重程度的差异。