Pauwels Ernest K J, Erba Paola
Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
Drug News Perspect. 2007 May;20(4):213-20. doi: 10.1358/dnp.2007.20.4.1103525.
Nanosystems have unique physical and biological properties. Various systems have been designed for medical use and offer promising ways of delivering drugs at high concentrations at sites of interest, e.g., cancer lesions, while reducing systemic side effects. Nanotechnology has also opened ways for the development of contrast agents and radiopharmaceuticals for specific targeting, which is presently changing research strategies in the field of magnetic resonance imaging, ultrasound imaging and nuclear medicine applications. This article aims to overview how "nanomedicine" is presently influencing drug design for diagnostic and therapeutic purposes.
纳米系统具有独特的物理和生物学特性。已经设计了各种系统用于医学用途,并提供了在感兴趣的部位(如癌症病灶)高浓度递送药物的有前景的方法,同时减少全身副作用。纳米技术还为开发用于特定靶向的造影剂和放射性药物开辟了道路,这正在改变磁共振成像、超声成像和核医学应用领域的研究策略。本文旨在概述“纳米医学”目前如何影响用于诊断和治疗目的的药物设计。