Patched1在初级纤毛处调节刺猬信号通路。

Patched1 regulates hedgehog signaling at the primary cilium.

作者信息

Rohatgi Rajat, Milenkovic Ljiljana, Scott Matthew P

机构信息

Departments of Developmental Biology, Genetics, and Bioengineering and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

出版信息

Science. 2007 Jul 20;317(5836):372-6. doi: 10.1126/science.1139740.

DOI:10.1126/science.1139740

PMID:17641202

Abstract

Primary cilia are essential for transduction of the Hedgehog (Hh) signal in mammals. We investigated the role of primary cilia in regulation of Patched1 (Ptc1), the receptor for Sonic Hedgehog (Shh). Ptc1 localized to cilia and inhibited Smoothened (Smo) by preventing its accumulation within cilia. When Shh bound to Ptc1, Ptc1 left the cilia, leading to accumulation of Smo and activation of signaling. Thus, primary cilia sense Shh and transduce signals that play critical roles in development, carcinogenesis, and stem cell function.

摘要

原发性纤毛对于哺乳动物中刺猬信号通路（Hh）的信号转导至关重要。我们研究了原发性纤毛在音猬因子（Shh）的受体Patched1（Ptc1）调控中的作用。Ptc1定位于纤毛，并通过阻止Smoothened（Smo）在纤毛内积累来抑制它。当Shh与Ptc1结合时，Ptc1离开纤毛，导致Smo积累并激活信号传导。因此，原发性纤毛感知Shh并转导在发育、致癌作用和干细胞功能中起关键作用的信号。