Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu, China.
Hepatol Res. 2007 Dec;37(12):1044-51. doi: 10.1111/j.1872-034X.2007.00121.x. Epub 2007 Jul 21.
We explored the pattern of hepatic venous outflow reconstruction in adult right lobe (segments V5-8) living donor liver transplantation (LDLT) without the middle hepatic vein (MHV). The difficulty and challenge of LDLT without MHV is the outflow reconstruction of hepatic vein. We have modified the surgical procedure and here report the results.
Retrospective analysis was made of the clinical data of 50 recipients who underwent LDLT using right lobe without MHV.
Forty-five recipients (90.0%, 45/50) are alive at median follow up of 10 months. The graft-to-recipient bodyweight ratio (GRWR) was 1.21% +/- 0.49% (range, 0.72% to 1.98%). The recipients of GRWR <0.8% (extra-small graft), 0.8% < GRWR < 1.2% (small graft) and GRWR > 1.2% (ideal graft) were 14, 27 and 9, respectively. Total ratio venous outflowreconstruction of V5, V8 and inferior right hepatic vein was 66.0% (33/50). The overall incidence of small-for-size syndrome was 10.0% (n = 5), the overall graft survival rate was 92.0% (46/50).
Graft function and survival rates are not only influenced by graft size, but also by hepatic venous outflow reconstruction; the 'multiple-opening vertical anastomosis' for reconstruction of hepatic vein outflow was used when the GRWR was smaller than 1.2%. This technique alleviates surgical risk in living donors, ensures excellent venous drainage, and reduces the incidence of small-for-size syndrome.
我们探讨了成人右半肝(V5-8 段)活体肝移植(LDLT)中无中肝静脉(MHV)时肝静脉流出重建的模式。无 MHV 的 LDLT 的难点和挑战是肝静脉的流出重建。我们已经修改了手术程序,在此报告结果。
回顾性分析了 50 例接受无 MHV 右半肝 LDLT 的受者的临床资料。
45 例受者(90.0%,45/50)在中位随访 10 个月时存活。供体与受体体重比(GRWR)为 1.21% +/- 0.49%(范围,0.72%至 1.98%)。GRWR<0.8%(超小供肝)、0.8%<GRWR<1.2%(小供肝)和 GRWR>1.2%(理想供肝)的受者分别为 14、27 和 9 例。V5、V8 和右肝下段静脉的总静脉流出重建比例为 66.0%(33/50)。小肝综合征的总发生率为 10.0%(n=5),总体移植物存活率为 92.0%(46/50)。
移植物功能和存活率不仅受移植物大小的影响,还受肝静脉流出重建的影响;当 GRWR 小于 1.2%时,采用“多开口垂直吻合”重建肝静脉流出。该技术减轻了活体供者的手术风险,确保了良好的静脉引流,并降低了小肝综合征的发生率。