载脂蛋白N-乙酰半胱氨酸和乙醇对大鼠脑出血所致脑损伤的影响。
Effects of apocynin and ethanol on intracerebral haemorrhage-induced brain injury in rats.
作者信息
Titova Elena, Ostrowski Robert P, Sowers Lawrence C, Zhang John H, Tang Jiping
机构信息
Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, California 92354, USA.
出版信息
Clin Exp Pharmacol Physiol. 2007 Sep;34(9):845-50. doi: 10.1111/j.1440-1681.2007.04664.x.
Abstract
- In the present study, we investigated whether the administration of apocynin, an NADPH oxidase inhibitor, provided brain protection in a rat model of intracerebral haemorrhage (ICH). 2. Rats were divided into sham, ICH untreated, ICH treated with vehicle (ethanol) and ICH treated with apocynin groups. Intracerebral haemorrhage was induced by collagenase injection. Neurological function, haemorrhage volume and brain oedema were measured 24 h after ICH. 3. Intracerebral haemorrhage caused significant neurological deficit associated with brain oedema. Apocynin (3, 10 and 30 mg/kg) failed to reduce brain injury after ICH. Low dose ethanol (0.2 g/kg) improved neurological function and reduced brain oedema (ICH-vehicle vs ICH-untreated, P < 0.05). 4. In conclusion, apocynin has no neuroprotective effect when administered intraperitoneally after ICH.
摘要
- 在本研究中，我们调查了给予NADPH氧化酶抑制剂白杨素是否能在大鼠脑出血（ICH）模型中提供脑保护作用。2. 将大鼠分为假手术组、未治疗的ICH组、用溶媒（乙醇）治疗的ICH组和用白杨素治疗的ICH组。通过注射胶原酶诱导脑出血。在脑出血后24小时测量神经功能、出血量和脑水肿。3. 脑出血导致与脑水肿相关的显著神经功能缺损。白杨素（3、10和30mg/kg）未能减轻脑出血后的脑损伤。低剂量乙醇（0.2g/kg）改善了神经功能并减轻了脑水肿（ICH-溶媒组与未治疗的ICH组相比，P<0.05）。4. 总之，脑出血后腹腔注射白杨素没有神经保护作用。
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