对正常及四氧嘧啶诱导的糖尿病大鼠，尖叶蚁栖树茎皮水提取物和乙醇提取物的降血糖及抗糖尿病活性研究

Hypoglycemic and antidiabetic activities on the stem bark aqueous and ethanol extracts of Musanga cecropioides in normal and alloxan-induced diabetic rats.

作者信息

Adeneye A A, Ajagbonna O P, Ayodele O W

机构信息

Department of Pharmacology, Lagos State University of Medicine, P.M.B. 21266, Ikeja, Lagos State, Nigeria.

出版信息

Fitoterapia. 2007 Dec;78(7-8):502-5. doi: 10.1016/j.fitote.2007.05.001. Epub 2007 Jul 3.

DOI:10.1016/j.fitote.2007.05.001

PMID:17651918

Abstract

Daily oral administration of the aqueous and ethanolic extracts of Musanga cecropioides stem bark in normal and diabetic rats at doses of 250, 500 and 1000 mg/kg/day, for 14 days significantly lowered the fasting plasma glucose levels in normal and alloxan-induced diabetic rats in dose-dependent fashion. The ethanol extract induced more significant antidiabetic effect than the aqueous extract.

摘要

在正常和糖尿病大鼠中，每天口服250、500和1000毫克/千克/天剂量的非洲塞克罗比亚树茎皮水提取物和乙醇提取物，持续14天，能以剂量依赖方式显著降低正常大鼠和四氧嘧啶诱导的糖尿病大鼠的空腹血糖水平。乙醇提取物比水提取物诱导出更显著的抗糖尿病作用。