围产期窒息后人新生儿脊髓中的硝基酪氨酸
Nitrotyrosine in human neonatal spinal cord after perinatal asphyxia.
作者信息
Groenendaal Floris, Vles Johannes, Lammers Harry, De Vente Jan, Smit Diane, Nikkels Peter G J
机构信息
Department of Neonatology, University Medical Center Utrecht, Utrecht, The Netherlands.
出版信息
Neonatology. 2008;93(1):1-6. doi: 10.1159/000106432. Epub 2007 Jul 25.
BACKGROUND
Spinal cord injury has been reported after perinatal asphyxia in full-term neonates.
OBJECTIVES
To examine the role of excessive nitric oxide production in perinatal spinal cord injury.
SUBJECTS AND METHODS
Tissue samples of 18 full-term neonates who died of hypoxic-ischemic encephalopathy were analyzed for the presence of nitrotyrosine (NT).
RESULTS
NT was demonstrated in 5 of these 18 neonates. In addition, activated caspase 3, a marker of apoptosis, and CD68, as a marker of inflammation, could be demonstrated in some infants.
CONCLUSIONS
excessive nitric oxide production and subsequent NT formation is seen in spinal cord tissue after severe perinatal asphyxia. This finding may be relevant for the development of neuroprotective strategies.
背景
足月新生儿围产期窒息后曾有脊髓损伤的报道。
目的
探讨一氧化氮产生过多在围产期脊髓损伤中的作用。
对象与方法
对18例死于缺氧缺血性脑病的足月新生儿的组织样本进行硝基酪氨酸（NT）检测。
结果
这18例新生儿中有5例检测到NT。此外，在部分婴儿中可检测到凋亡标志物活化半胱天冬酶3以及炎症标志物CD⁶⁸。
结论
严重围产期窒息后脊髓组织中可见一氧化氮产生过多及随后的NT形成。这一发现可能与神经保护策略的制定有关。
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