伴有克隆性染色体畸变的软组织骨化性纤维黏液样肿瘤。
Ossifying fibromyxoid tumor of soft parts with clonal chromosomal aberrations.
作者信息
Kawashima Hiroyuki, Ogose Akira, Umezu Hajime, Hotta Tetsuo, Tohyama Tsuyoshi, Tsuchiya Masahiko, Endo Naoto
机构信息
Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510 Japan.
出版信息
Cancer Genet Cytogenet. 2007 Jul 15;176(2):156-60. doi: 10.1016/j.cancergencyto.2007.04.009.
Ossifying fibromyxoid tumor (OFMT) is a rare but morphologically distinctive soft-tissue tumor. The histologic origin of this tumor is not clearly known, but its various features suggest a schwannian, neuronal, or chondroid origin. We herein report a case of a typical OFMT that occurred in the shoulder of a 65-year-old man. The karyotype exhibited the following complex numeric and structural aberrations: 42 approximately 46,XY,-Y,add(1)(q42),add(6)(p21),t(10;18)(q26;q11),der(11)t(11;15)(q23;q15),add(12)(q13),ins(14;?)(q13;?),-15,+mar. Combined with several previously reported studies, these aberrations could not identify a common cytogenetic abnormality in OFMT.
骨化性纤维黏液样肿瘤（OFMT）是一种罕见但形态独特的软组织肿瘤。该肿瘤的组织学起源尚不清楚，但其各种特征提示其起源于雪旺细胞、神经元或软骨样细胞。我们在此报告一例发生于一名65岁男性肩部的典型OFMT病例。核型显示出以下复杂的数字和结构异常：42约46，XY，-Y，add(1)(q42)，add(6)(p21)，t(10;18)(q26;q11)，der(11)t(11;15)(q23;q15)，add(12)(q13)，ins(14;?)(q13;?)，-15，+mar。结合此前几项已发表的研究，这些异常未能在OFMT中识别出常见的细胞遗传学异常。
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