Nikliński J, Furman M, Palynyczko Z, Laudański J, Bułatowicz J
Clinic of Chest Surgery, Medical Academy, Białystok, Poland.
Neoplasma. 1991;38(6):645-51.
Carcinoembryonic antigen (CEA), neuron-specific enolase (NSE) and creatine kinase-BB (CK-BB) were estimated in blood serum of 75 patients with primary lung carcinoma and of 20 patients with nonmalignant lung diseases. CEA and NSE were determined by immunoenzymatic method using monoclonal antibodies (Abbott CEA-EIA and Roche NSE-EIA) and CK-BB was assayed using kits supplied by Boehringer-Mannheim (Monotest CK-NAC aktiviert). Enhanced levels of CEA were observed in 64% of patients with lung carcinoma, mainly with adenocarcinoma. Increased activities of NSE and CK-BB were obtained in 47% and 39% of patients, respectively, principally of those with small cell carcinoma. The CEA level was dependent on the stage of advanced NSCLC carcinoma and of NSE and CK-BB on the stage of advanced SCLC carcinoma. The complex analysis of the three markers has given 100% specificity of test.
对75例原发性肺癌患者和20例非恶性肺部疾病患者的血清进行癌胚抗原（CEA）、神经元特异性烯醇化酶（NSE）和肌酸激酶BB（CK-BB）检测。采用单克隆抗体免疫酶法（雅培CEA-EIA和罗氏NSE-EIA）测定CEA和NSE，使用勃林格殷格翰提供的试剂盒（单测试CK-NAC活化）检测CK-BB。64%的肺癌患者CEA水平升高，主要为腺癌患者。47%的患者NSE活性增加，39%的患者CK-BB活性增加，主要为小细胞癌患者。CEA水平取决于晚期非小细胞肺癌的分期，NSE和CK-BB水平取决于晚期小细胞肺癌的分期。对这三种标志物的综合分析使检测具有100%的特异性。
