金刚烷胺治疗运动减少性言语障碍：对失语症可能有益？
Amantadine for adynamic speech: possible benefit for aphasia?
作者信息
Barrett Anna M, Eslinger Paul J
机构信息
Stroke Rehabilitation Research Program, Kessler Medical Rehabilitation Research and Education Corporation, West Orange, New Jersey 07052, USA.
出版信息
Am J Phys Med Rehabil. 2007 Aug;86(8):605-12. doi: 10.1097/PHM.0b013e31811473b3.
OBJECTIVE
Dopaminergic agents may stimulate behavior and verbal expression after frontal lobe dysfunction. Although amantadine is used in neurorehabilitation of motivational disorders and head injury, it is not commonly prescribed to improve aphasia. This pilot study examined verbal fluency on and off amantadine for nonfluent speech.
DESIGN
Four participants undergoing inpatient rehabilitation, meeting criteria for transcortical motor aphasia had stroke (2), stroke postaneurysm surgery (1), or brain tumor resection (1). We administered 100 mg of amantadine twice a day in an open-label, on-off protocol, with multiple assessments per on-off period.
RESULTS
Off medication, subjects generated a mean 12.62 of words (abnormally few) on the Controlled Oral Word Association test. On medication, word generation significantly improved to 17.71 words (P = 0.04), although scores remained psychometrically in the abnormal range.
CONCLUSIONS
Further research on amantadine, specifically for nonfluent speech and nonfluent aphasia, including effects on functional communication and control conditions, may be warranted.
目的
多巴胺能药物可能会刺激额叶功能障碍后的行为和言语表达。尽管金刚烷胺用于动机障碍和头部损伤的神经康复，但它通常不被用于改善失语症。这项初步研究考察了服用和停用金刚烷胺对非流畅性言语的言语流畅性的影响。
设计
四名接受住院康复治疗的参与者，符合经皮质运动性失语症标准，病因分别为中风（2例）、动脉瘤手术后中风（1例）或脑肿瘤切除术后（1例）。我们采用开放标签的服药-停药方案，每天两次给予100毫克金刚烷胺，每个服药-停药周期进行多次评估。
结果
在停药期间，受试者在受控口语单词联想测试中平均说出12.62个单词（异常少）。服药期间，单词生成显著改善至17.71个单词（P = 0.04），尽管分数在心理测量学上仍处于异常范围。
结论
可能有必要对金刚烷胺进行进一步研究，特别是针对非流畅性言语和非流畅性失语症，包括其对功能性沟通和对照条件的影响。
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