普拉地诺内酯B和FD - 895的合成方法。
A synthetic entry to pladienolide B and FD-895.
作者信息
Mandel Alexander L, Jones Brian D, La Clair James J, Burkart Michael D
机构信息
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
出版信息
Bioorg Med Chem Lett. 2007 Sep 15;17(18):5159-64. doi: 10.1016/j.bmcl.2007.06.094. Epub 2007 Jul 7.
Abstract
Presented within are syntheses of the pladienolide B and FD-895 side-chains, as well as models of the essential ring-closing metathesis and Stille coupling that will be used to complete their total syntheses. Several analogs of the pladienolide B side-chain were also prepared in order to evaluate the scope of the methodology and to create a library of structures that could be used for stereochemical and SAR analyses.
摘要
本文展示了普拉地诺内酯B和FD - 895侧链的合成方法，以及用于完成其全合成的关键闭环复分解反应和施蒂勒偶联反应的模型。还制备了普拉地诺内酯B侧链的几种类似物，以评估该方法的适用范围，并创建一个可用于立体化学和构效关系分析的结构库。
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