健康与疾病状态下的呼吸道防御机制。

Respiratory defenses in health and disease.

作者信息

Cohn Leah A, Reinero Carol R

机构信息

Department of Veterinary Medicine and Surgery, University of Missouri-Columbia College of Veterinary Medicine, Columbia, MO 65211, USA.

出版信息

Vet Clin North Am Small Anim Pract. 2007 Sep;37(5):845-60, v. doi: 10.1016/j.cvsm.2007.05.003.

DOI:10.1016/j.cvsm.2007.05.003

PMID:17693202

Abstract

Every breath holds the potential to introduce infectious organisms and irritating particulates into the respiratory tract. Despite this continuous exposure, the lungs usually remain sterile. Further, potential pathogens are distinguished from innocuous particulates, thus sparing the respiratory tract from damaging inflammation. The article reviews the complex defenses used to protect the respiratory tract and also discusses the implications of failed defense systems.

摘要

每一次呼吸都有可能将感染性生物体和刺激性颗粒引入呼吸道。尽管持续接触这些物质，但肺部通常仍保持无菌状态。此外，潜在病原体与无害颗粒得以区分，从而使呼吸道免受破坏性炎症的侵害。本文综述了用于保护呼吸道的复杂防御机制，并讨论了防御系统失效的影响。