Tseng Tai-Chung, Liu Chun-Jen, Chen Pei-Jer, Lai Ming-Yang, Lin Chih-Lin, Kao Jia-Horng, Chen Ding-Shinn
Department of Internal Medicine, Division of Gastroenterology, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.
Liver Int. 2007 Sep;27(7):983-8. doi: 10.1111/j.1478-3231.2007.01546.x.
Hepatitis B virus (HBV) genotype C (HBV/C) has two subgenotypes: HBV/Cs and Ce. The prevalence and clinical implications of subgenotype Cs and Ce in Taiwanese HBV carriers remain unknown.
Subgenotypes of HBV/C were determined in 242 Taiwanese HBV carriers with various stages of liver disease. The clinical as well as virologic features between patients with HBV/Cs and HBV/Ce infection were further compared.
HBV/Ce was the predominant subgenotype in Taiwan. The prevalence of HBV/Ce was 93.6% in the inactive carriers group, 84.2% in chronic hepatitis patients, 81.2% in cirrhosis patients, 92.5% in hepatocellular carcinoma (HCC) patients without cirrhosis and 91.9% in HCC patients with cirrhosis. There was no significant difference in the distribution of the HBV/C subgenotypes among patients with different stages of liver disease.
Subgenotypes of HBV/C may not have a clinical impact on the disease progression of chronic hepatitis B in Taiwan.
乙型肝炎病毒（HBV）C基因型（HBV/C）有两个亚型：HBV/Cs和Ce。HBV/Cs和Ce亚型在台湾HBV携带者中的流行情况及临床意义尚不清楚。
对242例处于不同肝病阶段的台湾HBV携带者进行HBV/C亚型测定。进一步比较HBV/Cs感染患者和HBV/Ce感染患者的临床及病毒学特征。
HBV/Ce是台湾的主要亚型。在非活动性携带者组中，HBV/Ce的流行率为93.6%，慢性肝炎患者中为84.2%，肝硬化患者中为81.2%，无肝硬化的肝细胞癌（HCC）患者中为92.5%，有肝硬化的HCC患者中为91.9%。不同肝病阶段患者中HBV/C亚型的分布无显著差异。
HBV/C亚型可能对台湾慢性乙型肝炎的疾病进展没有临床影响。
