杜普伊特伦挛缩症：历史、诊断与治疗
Dupuytren's disease: history, diagnosis, and treatment.
作者信息
Shaw Robert B, Chong Alphonsus K S, Zhang Andrew, Hentz Vincent R, Chang James
机构信息
Stanford and Palo Alto, Calif. From the Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, and the Veterans Affairs Palo Alto Health Care System.
出版信息
Plast Reconstr Surg. 2007 Sep;120(3):44e-54e. doi: 10.1097/01.prs.0000278455.63546.03.
LEARNING OBJECTIVES
After studying this article, the participant should be able to: 1. Describe the clinical features of the disease. 2. Describe the pathoanatomical structures in Dupuytren's disease. 3. Outline the various factors associated with Dupuytren's disease. 4. Describe the modalities for surgical and nonsurgical treatment of the condition. 5. Outline recent biomolecular knowledge about the basis of Dupuytren's disease.
SUMMARY
Dupuytren's disease is characterized by nodule formation and contracture of the palmar fascia, resulting in flexion deformity of the fingers and loss of hand function. The authors review the historical background, clinical features, and current therapy of Dupuytren's disease; preview treatment innovations; and present molecular data related to Dupuytren's disease. These new findings may improve screening for Dupuytren's disease and provide a better understanding of the disease's pathogenesis.
学习目标
在研读本文后，参与者应能够：1. 描述该疾病的临床特征。2. 描述杜普伊特伦挛缩症的病理解剖结构。3. 概述与杜普伊特伦挛缩症相关的各种因素。4. 描述该病症的手术和非手术治疗方式。5. 概述关于杜普伊特伦挛缩症基础的最新生物分子知识。
总结
杜普伊特伦挛缩症的特征是掌腱膜形成结节并挛缩，导致手指屈曲畸形和手部功能丧失。作者回顾了杜普伊特伦挛缩症的历史背景、临床特征和当前治疗方法；预览了治疗创新；并展示了与杜普伊特伦挛缩症相关的分子数据。这些新发现可能会改善对杜普伊特伦挛缩症的筛查，并更好地理解该疾病的发病机制。
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