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[使用带覆膜可取出金属内支架及纵隔引流治疗大型食管穿孔和纵隔炎]

[Treatment of large, esophageal perforations and mediastinitis with a covered, removable metallic endoprosthesis and mediastinal drainage].

作者信息

Solt Jeno, Sarlós Géza, Tabár Béla, Bertalan Andrea

机构信息

Baranya Megyei Kórház Gasztroenterológiai Osztály, Pécs.

出版信息

Orv Hetil. 2007 Aug 26;148(34):1601-7. doi: 10.1556/OH.2007.28053.

Abstract

The application of covered metallic stents in the treatment of benign strictures and perforations is still in the early stages, because their removal is difficult and may cause tissue proliferation. The therapeutic effect and the efficiency of a new method for the extraction of a removable metallic stent were examined in three patients treated for oesophageal perforation. Two of the three patients were dilated with a balloon catheter because of corrosive oesophageal stenosis, and the oesophagus was perforated. In one patient mediastinal drainage, and jejunostomy and in the other primary suturing and drainage were performed. Sepsis and mediastinitis developed due to the oesophageal perforation and the fistula caused by the mediastinal drain in the first patient, and the insufficiency of the suture in the second patient. The oesophageal defects were sealed on day 8 and 10 after the perforation, and surgery by a covered stent. In the third patient, the oesophageal rupture caused by the dilatation and the attempt to stent a malignant obstruction was sealed with a covered stent within 2 hours. Parenteral nutrition and broad-spectrum antibiotic therapy were started. Three days after the interventions, swallowing tests with water-soluble contrast medium (Gastrografin) did not reveal any extravasations. Feeding via a nasogastric tube, and later oral feeding was started. After transient mediastinal drainage, the stents were removed on day 35 and 74 after implantation. Both openings healed completely. Restenoses above the stents were dilated again. The rupture of the malignant oesophagus in the third patient, following early, permanent stenting, healed without drainage and with no complications. Even with mediastinitis and concomitant sepsis, large oesophageal perforations can be treated successfully with removable, covered metallic stents and adequate mediastinal drainage.

摘要

覆膜金属支架在良性狭窄和穿孔治疗中的应用仍处于早期阶段,因为其取出困难且可能导致组织增生。我们对三名食管穿孔患者采用一种新型可取出金属支架取出方法的治疗效果和效率进行了研究。三名患者中有两名因腐蚀性食管狭窄接受了球囊导管扩张,随后食管穿孔。一名患者进行了纵隔引流、空肠造口术,另一名患者进行了一期缝合和引流。第一名患者因食管穿孔以及纵隔引流导致的瘘管引发了脓毒症和纵隔炎,第二名患者则因缝合不充分出现问题。穿孔后第8天和第10天,通过覆膜支架对食管缺损进行了封堵和手术。在第三名患者中,扩张及试图对恶性梗阻置入支架导致的食管破裂在2小时内用覆膜支架进行了封堵。开始了肠外营养和广谱抗生素治疗。干预三天后,使用水溶性造影剂(泛影葡胺)进行吞咽试验未发现任何渗漏。开始通过鼻胃管喂养,随后改为口服喂养。经过短暂的纵隔引流后,在植入后第35天和第74天取出了支架。两个开口均完全愈合。支架上方的再狭窄再次进行了扩张。第三名患者恶性食管破裂在早期永久性置入支架后愈合,未进行引流且无并发症。即使伴有纵隔炎和脓毒症,大的食管穿孔也可通过可取出的覆膜金属支架及充分的纵隔引流成功治疗。

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