胶质瘤的潜在生物化学疗法。

Potential biochemical therapy of glioma cancer.

作者信息

Yin Li-Tian, Fu Yue-Jun, Xu Qiao-Ling, Yang Jun, Liu Zeng-Li, Liang Ai-Hua, Fan Xiao-Jun, Xu Cheng-Gang

机构信息

Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan 030006, PR China.

出版信息

Biochem Biophys Res Commun. 2007 Oct 19;362(2):225-9. doi: 10.1016/j.bbrc.2007.07.167. Epub 2007 Aug 8.

DOI:10.1016/j.bbrc.2007.07.167

PMID:17707767

Abstract

Glioma is a highly invasive, rapidly spreading form of brain cancer that is resistant to surgical and medical treatment. The recent progresses made in intracellular and ion channels of glioma cells provide a potential new approach for biochemical therapy of brain tumor. In this paper, we reviewed clinical data on chemotherapy by temozolomide and results from new studies on voltage-gated potassium channels, large-conductance Ca(2+)-activated K(+) channels, volume-activated chloride channels, glioma-specific chloride channel and their modulators. These new findings may represent future directions for brain tumor studies and treatment.

摘要

神经胶质瘤是一种具有高度侵袭性、迅速扩散的脑癌形式，对手术和药物治疗均具有抗性。神经胶质瘤细胞的细胞内和离子通道方面的最新进展为脑肿瘤的生化治疗提供了一种潜在的新方法。在本文中，我们综述了替莫唑胺化疗的临床数据以及关于电压门控钾通道、大电导钙激活钾通道、容积激活氯通道、神经胶质瘤特异性氯通道及其调节剂的新研究结果。这些新发现可能代表了脑肿瘤研究和治疗的未来方向。