Sweet Matthew P, Nipomnick Ian, Gasper Warren J, Bagatelos Karen, Ostroff James W, Fisichella Piero M, Way Lawrence W, Patti Marco G
Department of Surgery, University of California San Francisco, San Francisco, CA 94143-0790, USA.
J Gastrointest Surg. 2008 Jan;12(1):159-65. doi: 10.1007/s11605-007-0275-z. Epub 2007 Aug 21.
In the past, a Heller myotomy was considered to be ineffective in patients with achalasia and a markedly dilated or sigmoid-shaped esophagus. Esophagectomy was the standard treatment. The aims of this study were (a) to evaluate the results of laparoscopic Heller myotomy and Dor fundoplication in patients with achalasia and various degrees of esophageal dilatation; and (b) to assess the role of endoscopic dilatation in patients with postoperative dysphagia. One hundred and thirteen patients with esophageal achalasia were separated into four groups based on the maximal diameter of the esophageal lumen and the shape of the esophagus: group A, diameter<4.0 cm, 46 patients; group B, esophageal diameter 4.0-6.0 cm, 32 patients; group C, diameter>6.0 cm and straight axis, 23 patients; and group D, diameter>6.0 cm and sigmoid-shaped esophagus, 12 patients. All had a laparoscopic Heller myotomy and Dor fundoplication. The median length of follow-up was 45 months (range 7 months to 12.5 years). The postoperative recovery was similar among the four groups. Twenty-three patients (20%) had postoperative dilatations for dysphagia, and five patients (4%) required a second myotomy. Excellent or good results were obtained in 89% of group A and 91% of groups B, C, and D. None required an esophagectomy to maintain clinically adequate swallowing. These data show that (a) a laparoscopic Heller myotomy relieved dysphagia in most patients with achalasia, even when the esophagus was dilated; (b) about 20% of patients required additional treatment; (c) in the end, swallowing was good in 90%.
过去,人们认为对于贲门失弛缓症且食管明显扩张或呈乙状结肠形的患者,Heller肌层切开术无效。食管切除术是标准治疗方法。本研究的目的是:(a)评估腹腔镜Heller肌层切开术和Dor胃底折叠术治疗不同程度食管扩张的贲门失弛缓症患者的效果;(b)评估内镜扩张在术后吞咽困难患者中的作用。113例食管贲门失弛缓症患者根据食管腔最大直径和食管形状分为四组:A组,直径<4.0 cm,46例患者;B组,食管直径4.0 - 6.0 cm,32例患者;C组,直径>6.0 cm且食管轴呈直线形,23例患者;D组,直径>6.0 cm且食管呈乙状结肠形,12例患者。所有患者均接受了腹腔镜Heller肌层切开术和Dor胃底折叠术。随访时间中位数为45个月(范围7个月至12.5年)。四组患者术后恢复情况相似。23例患者(20%)因吞咽困难接受了术后扩张,5例患者(4%)需要再次进行肌层切开术。A组89%以及B、C、D组91%的患者获得了优异或良好的效果。无一例患者需要进行食管切除术以维持临床上足够的吞咽功能。这些数据表明:(a)腹腔镜Heller肌层切开术可缓解大多数贲门失弛缓症患者的吞咽困难,即使食管已扩张;(b)约20%的患者需要额外治疗;(c)最终,90%的患者吞咽功能良好。