N-乙酰半胱氨酸可减少消退反应，并能持久降低线索诱导和海洛因诱导的觅药行为。
N-acetylcysteine reduces extinction responding and induces enduring reductions in cue- and heroin-induced drug-seeking.
作者信息
Zhou Wenhua, Kalivas Peter W
机构信息
Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
出版信息
Biol Psychiatry. 2008 Feb 1;63(3):338-40. doi: 10.1016/j.biopsych.2007.06.008. Epub 2007 Aug 24.
BACKGROUND
Previous studies show that the acute administration of N-acetylcysteine (NAC) inhibits the desire for cocaine in addicts and cocaine-seeking in animals.
METHODS
Rats were trained to self-administer heroin, and the reinstatement model of drug seeking was used to determine whether chronic NAC treatment inhibited heroin-seeking.
RESULTS
Daily NAC administration inhibited cue- and heroin-induced seeking. Moreover, repeated NAC administration during extinction training reduced extinction-responding and inhibited cue- and heroin-induced reinstatement for up to 40 days after discontinuing daily NAC injection.
CONCLUSIONS
These data show that daily NAC inhibits heroin-induced reinstatement and produces an enduring reduction in cue- and heroin-induced drug seeking for over 1 month after the last injection of NAC. Both the inhibitory effect of NAC on the reinstatement of heroin-seeking and the ability of NAC to reduce extinction-responding support clinical evaluation of repeated NAC administration to decrease in drug-seeking in heroin addicts.
背景
先前的研究表明，急性给予N-乙酰半胱氨酸（NAC）可抑制成瘾者对可卡因的渴望以及动物对可卡因的觅求行为。
方法
训练大鼠自我注射海洛因，并采用药物觅求的复吸模型来确定长期给予NAC治疗是否会抑制海洛因觅求行为。
结果
每日给予NAC可抑制线索和海洛因诱导的觅求行为。此外，在消退训练期间重复给予NAC可减少消退反应，并在停止每日NAC注射后长达40天内抑制线索和海洛因诱导的复吸。
结论
这些数据表明，每日给予NAC可抑制海洛因诱导的复吸，并在最后一次注射NAC后的1个多月内持续减少线索和海洛因诱导的药物觅求行为。NAC对海洛因觅求复吸的抑制作用以及NAC减少消退反应的能力均支持对重复给予NAC以减少海洛因成瘾者药物觅求行为进行临床评估。
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